Ronald Jansen , Protein - Protein Interactions from Genomic Data A Bayesian Networks Approach for Predicting
نویسنده
چکیده
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A Bayesian networks approach for predicting protein-protein interactions from genomic data.
We have developed an approach using Bayesian networks to predict protein-protein interactions genome-wide in yeast. Our method naturally weights and combines into reliable predictions genomic features only weakly associated with interaction (e.g., messenger RNAcoexpression, coessentiality, and colocalization). In addition to de novo predictions, it can integrate often noisy, experimental intera...
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